DNA- the genetic code located in the Nucleus. Any mutation in it can have major consequences. Such as with Gaucher disease, a few letters switched around in the code make the body unable to get ride of lipid build up. mRNA- an RNA molecule responsible for conveying information from the DNA to tRNA tRNA- an RNA molecule responsible for matchig up its anti codons with the mRNA codons allowing the proper polypeptide chain to be formed Polypeptide Chain- Created in the ribosome using mRNA and tRNA. It fold into a protein. |
Translation- a step in the Protein synthesis process where mRNA is matched with the anti-codons of tRNA and a polypeptide is formed. Nucleus- a cell organelle responsible for holding the DNA Ribosome- a cell organelle responsible for using mRNA and tRNA to create the final polypeptide chain. Folding- After the polypeptide is formed, it folds into a protein. The protein shape determines its function. If it is folded into the wrong protein then diseases like Gaucher can form. |
Protein- A macro molecule responsible for many tasks such as sending messages, transporting molecules and making up structures. They are made by protein synthesis. Since they are specific to their tasks a change in the DNA can create an different protein which can greatly affect the body's functionality. In Gaucher disease the glucocerebrosidase enzyme protein is made faulty. Anti Codon- located on tRNA. They match up with codons to form the proper sequence in the polypeptide. Codon- located on mRNA. They match up with anti codons to relay the proper sequence for the polypeptide from the DNA. |
DNA : tggcacaggg gtagttgtca agttgtagaa ttgaactagt tgcttcacta tgtcagtagc |
mRNA: accguguccc caucaacagu ucaacaucuu aacuugauca acgaagugau acagucaucg |
Polypeptide Sequence: Threonine Valine Serine Proline Serine Thrionine Valine Glutamine Serine Leucine Asparagine Leucine AsparticAcid Asparagine GlutamicAcid Valine AsparticAcid Glutamine Serine Serine |